{"id":7997,"date":"2021-02-26T08:52:09","date_gmt":"2021-02-26T08:52:09","guid":{"rendered":"https:\/\/www.mrpeasy.com\/blog\/?p=7997"},"modified":"2023-03-27T12:20:32","modified_gmt":"2023-03-27T12:20:32","slug":"sme-backbone-for-biotech-supply-chains","status":"publish","type":"post","link":"https:\/\/www.mrpeasy.com\/blog\/sme-backbone-for-biotech-supply-chains\/","title":{"rendered":"SME Backbone for Biotech Supply Chains"},"content":{"rendered":"\n<p>With Covid-19 vaccine delivery highlighting the need for resilience in pharma and biotech supply chains ERP\/MRP gives smaller suppliers the backbone required to take part.<\/p>\n\n\n\n<!--more-->\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><img loading=\"lazy\" decoding=\"async\" width=\"660\" height=\"330\" src=\"https:\/\/www.mrpeasy.com\/blog\/wp-content\/uploads\/2021\/05\/SME-backbone-for-biotech-supply-chains.jpg\" alt=\"SME-backbone-for-biotech-supply-chains\" class=\"wp-image-7998\" srcset=\"https:\/\/www.mrpeasy.com\/blog\/wp-content\/uploads\/2021\/05\/SME-backbone-for-biotech-supply-chains.jpg 660w, https:\/\/www.mrpeasy.com\/blog\/wp-content\/uploads\/2021\/05\/SME-backbone-for-biotech-supply-chains-300x150.jpg 300w\" sizes=\"auto, (max-width: 660px) 100vw, 660px\" \/><\/figure><\/div>\n\n\n\n<p>The pandemic has starkly revealed not only the science and research based strengths of the UK\u2019s pharmaceutical and biotechnology sector, but also the vulnerabilities of highly complex, geographically extended and time-critical supply chains. Identifying, controlling and mitigating these weaknesses has become an even greater priority, not just for \u2018big pharma\u2019 but for the very many smaller companies that make up the life sciences supply chain ecosystem. An essential foundation is a solid, reliable and useable ERP\/MRP backbone.<\/p>\n\n\n<div class=\"banner-v2\">\n    <p class=\"banner-v2__desc\">Looking for a reliable, SME-friendly ERP system?<\/p>\n    <a class=\"banner-v2__link\" href=\"https:\/\/www.mrpeasy.com\/sign-up\/\" target=\"_blank\" data-ga-event=\"blog_signup_banner_blue\">Try MRPeasy for free<\/a>\n<\/div>\t\t<style>.banner-v2 {\n    float: right;\n    display: flex;\n    flex-direction: column;\n    justify-content: center;\n    align-items: center;\n    padding: 40px 32px;\n    gap: 16px;\n    width: 356px;\n    height: 205px;\n    background: linear-gradient(199.68deg, #6084E5 13.17%, #5FA7DD 82.1%);\n    border-radius: 4px;\n    margin-left: 12px;\n    margin-bottom: 12px;\n    margin-top: 15px;\n}\n\n@media (max-width: 767.98px) {\n    .banner-v2 {\n         width: 100%;\n         height: 173px;\n         margin-bottom: 0;\n         margin-left: 0;\n    }\n}\n\n.single__content p.banner-v2__desc {\n    margin: 0 !important;\n}\n\np.banner-v2__desc {\n    width: 292px;\n    font-style: normal;\n    font-weight: 700;\n    font-size: 22px;\n    line-height: 29px !important;\n    text-align: center;\n    color: #FFFFFF;\n    margin: 0 !important;\n    order: 0 !important;\n}\n\n.single__content a.banner-v2__link {\n    color: #FFFFFF !important;\n}\n\n.single__content a.banner-v2__link:hover {\n    color: #003557 !important;\n}\n\na.banner-v2__link {\n    display: flex;\n    justify-content: center;\n    align-items: center;\n    width: 181px;\n    height: 51px;\n    padding: 18px 0;\n    border-radius: 4px;\n    background: #003557;\n    font-weight: 700;\n    font-size: 16px;\n    color: #FFFFFF !important;\n    text-decoration: none !important;\n    order: 1 !important;\n}\n\n.banner-v2__link:hover {\n    background: white;\n    color: #003557 !important;\n}<\/style>\n\t\t\n\n\n<p>The story of vaccine development, and indeed of pharmaceuticals generally, is usually told in terms of the major global corporation such as Pfizer and Astra Zeneca. Indeed, 37 of the global \u2018top 50\u2019 have operations in the UK, and 89% of employees in the biopharmaceutical sector work for firms with more than 250 employees. But in pharmaceutical products alone there were 645 UK manufacturing companies in 2018; including non-drug biotechnologies nearly 2,000; and across the whole life sciences sector, including not just therapy manufacturers but suppliers of diagnostics, equipment, and support services (for example, \u2018fill and finish\u2019), some 6,300 companies according to the BioIndustry Association, some 80% being small businesses.<\/p>\n\n\n\n<p>This SME ecosystem is in constant flux. New start-up companies are formed to exploit the scientific discoveries of the UK\u2019s world leading research institutions. Some of these are acquired by \u2018big pharma\u2019, others grow through external investment \u2013 UK biotech raised \u00a32.8 billion in capital in 2020. At the same time the major companies constantly spin off companies whose products don\u2019t sit easily in their commercial portfolio. Even within \u2018big pharma\u2019, there are often scientific or market constraints on \u2018scaling up\u2019 production, so that although units may enjoy \u2018corporate\u2019 services in sales, marketing, and securing regulatory approval, from a manufacturing point of view they may operate very much like small companies.<\/p>\n\n\n\n<p>And small-scale production is likely to become even more significant in the future. Developments in \u2018advanced therapies\u2019 such as genetic and cell-base treatments suggest a \u2018personalisation\u2019 of therapies. In future, \u2018batch size\u2019 may be that of an individual patient\u2019s requirement, while the short life and vulnerability of biological \u2013 as opposed to chemical \u2013 substances drive a requirement for on-demand production as close as possible to the point of use. This is somewhat analogous to the way 3D printing is expected to develop in other manufacturing sectors. Production and supply chain control can only get more complex.<\/p>\n\n\n\n<p>Small firms and start-ups don\u2019t get a free pass from regulatory requirements. Every input, every process and every deviation has to be meticulously logged and tracked. Resource planning has to be precise and highly detailed, not just around the actual manufacturing process but for resources such as cold chain logistics, or consumable and disposable inputs. Many vaccines, for example, are cultured in \u2018bioreactors\u2019 which are in essence sophisticated single-use plastic bags \u2013 often sourced, along with related tubing and so on, from Far Eastern manufacturers and vulnerable to the problems familiar from PPE procurement. Many chemical precursors, reagents and the like are also sourced from abroad.<\/p>\n\n\n\n<p>Non-production tasks, such as clean down and clearing between batches, and Quality Control have to be planned and scheduled in more detail than is usual. Synchronisation with suppliers, with contract manufacturers, with logistics operators and with clinical end-users has to be glitch-free otherwise, at best, valuable product is scrapped, at worst, patient health is compromised. Security, both physical and cyber, is of increasing concern. And many of the workarounds and comfort points familiar from other industries are not available \u2013 often, for example, the nature of the substances means that it is not possible to create buffer stocks of raw material, Work in Progress or finished product.<\/p>\n\n\n\n<p>An ERP\/MRP system to underpin this activity is not necessarily over-complex, but it does need to allow the finest granularity over multi-layer Bills of Material, upload and download seamlessly with other systems and with other supply chain partners, record and retain very large amounts of manufacturing data, and perhaps above all, produce reports that give clear and early warning of problems and deviations. The system also needs to be simple and intuitive in operation \u2013 users in small biotech companies are likely to be trained scientists, not production managers.<\/p>\n\n\n<div class=\"banner-v1\">\n    <div class=\"banner__text\">\n        <div class=\"banner-v1__title\">Your business deserves effective software<\/div>\n        <div class=\"banner-v1__desc\">MRPeasy users report a 54% average improvement in the overall performance of their company and a 42% increase in on-time deliveries.<\/div>\n        <div><a class=\"banner-v1__link\" href=\"https:\/\/www.mrpeasy.com\/sign-up\/\" target=\"_blank\" data-ga-event=\"blog_signup_banner_white\">Try for free<\/a><\/div>\n    <\/div>\n    <div class=\"banner__img\">\n        <img decoding=\"async\" src=\"https:\/\/www.mrpeasy.com\/blog\/wp-content\/themes\/mrpeasy\/assets\/images\/banner.svg\" alt=\"banner\">\n    <\/div>\n<\/div>\n\n\n\n<p>There is a lot of work being done currently on creating common standards and control methods around the emerging sciences such as genomics and cell-based therapies, but whatever form these take, there will still be a need for a Resource Planning \u2018backbone\u2019. In 2017, the Medicines Manufacturing Industry Partnership produced a \u2018Manufacturing Vision for UK Pharma\u2019 outlining the need to create flexible production facilities and adaptive supply chain handling, logistics and preservation technologies, and listing the key needs and drivers. These include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Robust and effective control of end-to-end supply from raw materials to finished goods, with measurements to support this;<\/li><li>Secure tracking \u2013 building on the control need, a capability to identify patient personalised product, especially with advanced therapies;<\/li><li>Development of a complex, cost effective and robust supply chain \u2013 including frozen, and class-leading preservation technologies<\/li><li>Close tracking history of products\/components: know where it is and what environmental conditions it has been in;<\/li><li>Increased integrated automation of systems where, currently, much is manual yet early demand signals are key<\/li><li>Smarter use of digital platforms to reduce expensive inventory and risk of stock outs.<\/li><\/ul>\n\n\n\n<p><em> First published in <\/em><a rel=\"noreferrer noopener nofollow\" aria-label=\"IT Supply Chain (opens in a new tab)\" href=\"https:\/\/itsupplychain.com\/sme-backbone-for-biotech-supply-chains\/\" target=\"_blank\"><em>IT Supply Chain<\/em><\/a><em>.<\/em><\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.mrpeasy.com\/blog\/wp-content\/uploads\/2021\/05\/EAS_SF_RGB_ENG-1024x298.png\" alt=\"EAS_SF_RGB_ENG\" class=\"wp-image-7994\" width=\"512\" height=\"149\" srcset=\"https:\/\/www.mrpeasy.com\/blog\/wp-content\/uploads\/2021\/05\/EAS_SF_RGB_ENG-1024x298.png 1024w, https:\/\/www.mrpeasy.com\/blog\/wp-content\/uploads\/2021\/05\/EAS_SF_RGB_ENG-300x87.png 300w, https:\/\/www.mrpeasy.com\/blog\/wp-content\/uploads\/2021\/05\/EAS_SF_RGB_ENG-768x223.png 768w, https:\/\/www.mrpeasy.com\/blog\/wp-content\/uploads\/2021\/05\/EAS_SF_RGB_ENG.png 1344w\" sizes=\"auto, (max-width: 512px) 100vw, 512px\" \/><\/figure><\/div>\n","protected":false},"excerpt":{"rendered":"<p>With Covid-19 vaccine delivery highlighting the need for resilience in pharma and biotech supply chains ERP\/MRP gives smaller suppliers the backbone required to take part.<\/p>\n","protected":false},"author":4,"featured_media":7998,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[44],"tags":[],"class_list":["post-7997","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-erp"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>SME Backbone for Biotech Supply Chains - Blog for Manufacturers and Distributors<\/title>\n<meta name=\"description\" content=\"With Covid-19 vaccine delivery highlighting the need for resilience in pharma and biotech supply chains. 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